Gina Gordon

Degree Program
: Microbiology Doctoral Training Program
Faculty Advisor: Brian Pfleger
Phone: (608) 265-0689
Email: gcgordon@wisc.edu

Current Research

I am studying RNA decay in industrially relevant microorganisms that are being used to produce high-value chemicals. RNA decay is an often-overlooked process that affects how much of a transcript is around and thus how much protein can be translated from that transcript. By better understanding the enzymes that are involved in this process and their specificity we may be able to better predict transcript abundance and expression levels. I am focusing on ribonuclease III (RNase III), which cleaves long double-stranded regions of RNA in a non-sequence specific manner. With better knowledge of the types of structures this enzyme can cleave, we can create tools genetic tools to manipulate transcript stability and lead to better predictions of protein expression levels based on nucleotide sequences.

Publications

Cameron, J. C., Gordon, G. C., & Pfleger, B. F. (2015). Genetic and genomic analysis of RNases in model cyanobacteria. Photosynthesis Research. http://doi.org/10.1007/s11120-015-0076-2

Markley, A. L., Begemann, M. B., Clarke, R. E., Gordon, G. C., & Pfleger, B. F. (2014). Synthetic Biology Toolbox for Controlling Gene Expression in the Cyanobacterium Synechococcus sp. strain PCC 7002. ACS Synthetic Biology. http://doi.org/dx.doi.org/10.1021/sb500260k

Abstract (PDF)

Resume (PDF)