Jason M. Lajoie 

Jason M. Lajoie

Degree Program: Chemical and Biological Engineering
Faculty Supervisor: Eric V. Shusta
Phone: (608) 265-3502
Email: jason.lajoie87@gmail.com

 

Current Research

The Blood Brain Barrier (BBB) plays an essential role in human health as it regulates the transport of materials into and out of the brain. Tight junctions between endothelial cells that line the vessels of the brain restrict the diffusion of soluble molecules from the blood to the brain. In addition, BBB endothelial cells posses a number of transporter proteins and receptors which serve to tightly regulate transport of a wide range of molecules. These properties are necessary for maintaining brain homeostasis and protecting the brain from unwanted toxins and pathogens. However, the barrier properties of the BBB also restrict transport into the brain of approximately 98% of small molecule drugs and 100% or protein pharmaceuticals which severely limits the development of treatments for a number of neurological diseases including Alzheimers and multiple sclerosis. Thus, the overall goal of my research is to investigate the membrane proteomics of the BBBB, specifically proteins involved in Receptor Mediated Trancytosis, in search of novel targets for drug delivery to the brain.

Abstract (PDF)

Resume (PDF)

 

 

 


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