Danielle C. Lohman

Danielle C. Lohman

Degree Program: Chemistry
Faculty Supervisor: David J. Pagliarini
Phone: (919) 349-3500
Email: dlohman@wisc.edu

 

Current Research

The Pagliarini lab investigates the biochemical basis for mitochondrial dysfunction. Disruptions of normal mitochondria function are associated with human diseases including type II diabetes, Parkinson’s disease, and Alzheimer’s disease.

Mitochondria are best known for their role in ATP production during oxidative phosphorylation. One essential component of the oxidative phosphorylation machinery is the electron transporter Coenzyme Q. My research focuses on understanding the enzymatic function and regulation of proteins involved in Coenzyme Q biosynthesis. Coenzyme Q is a lipophilic, redox active electron carrier required by the electron transport chain. Despite the importance of Coenzyme Q to human health, the pathway remains largely undefined and the biochemical regulation of Coenzyme Q biosynthesis is virtually unknown. Research into the biochemistry and regulation of proteins in this pathway will provide insight into mitochondrial disease associated with Coenzyme Q deficiency.

Publications

Lohman, D. C.; Edwards, D. R.; Wolfenden, R. “Hydrolysis of N-alkyl Sulfamates and the Catalytic Efficiency of an S-N Cleaving Sulfamidase” J.O.C. 2012, 77, 2907-2910.

Edwards, David R.; Lohman, D. C.; Wolfenden, R. “Catalytic proficiency: the extreme case of S-O cleaving sulfatases” J.A.C.S. 2012, 134, 525-531.

Abstract (PDF)

Resume (PDF)

 

 

 


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