Angela W. Xie 

Angela W. Xie

Degree Program: Biomedical Engineering
Faculty Supervisor: William Murphy
Phone: (920) 203-5689
Email: awxie@wisc.edu

Current Research

The goal of my proposed research is to develop a synthetic hydrogel array-based system to screen for individual and synergistic roles of ECM-mimetic cues in promoting EMT in human pluripotent stem cell culture. Poly(ethylene glycol) (PEG) hydrogels are an ideal choice for combinatorial screening of complex extracellular environments, as they allow for independent control over matrix biophysical and biochemical properties, and can be functionalized with bioactive moieties that mimic cell adhesion and growth factor-binding domains found in the native ECM. Thus, in conjunction with an enhanced-throughput array-based approach, PEG hydrogels present a valuable tool to efficiently deconstruct extracellular influences on EMT. Elucidation of matrix-derived cues that regulate EMT will strengthen our mechanistic understanding of mesodermal tissue morphogenesis and inform strategies to efficiently direct stem cell differentiation into mesoderm-specific lineages.

Publications

C. Williams, A.W. Xie, S. Emani, M. Yamato, T. Okano, S.M. Emani, and J.Y. Wong (2012) A comparison of human smooth muscle and mesenchymal stem cells as potential cell sources for tissue engineered vascular patches. Tissue Eng Part A 18, 986-998.

C. Williams, A.W. Xie, M. Yamato, T. Okano, and J.Y. Wong (2011) Stacking of aligned cell sheets for layer-by-layer control of complex tissue structure. Biomaterials 32, 5625-5632.

Abstract (PDF)

Resume (PDF)

 

 

 


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