Development of bacteriophage with expanded host range for selective infection of pathogenic bacteria
The M13 bacteriophage has been widely studied due to its extensive use in the field of phage display. However, due to the inherent inability of the phage to infect bacteria other than its traditional E. coli host, its use in medical field and in studies using other bacteria have been severely limited. I am working to develop a platform to allow for specific host range expansion of the M13 bacteriophage. This platform will then be applied to allow for the development of phage which can target a variety of pathogenic bacteria.