Position title: Integrated Program in Biochemistry
- Michael Cox
Genome stability proteins Uup and MgsA
My research is split into two different projects while I settle into one of them as a thesis project. Each project is based on a genome stability protein. The two proteins are MgsA and Uup. Uup supresses deletions of genetic material in E. Coli through some unknown mechanism. I aim to understand this process by characterizing the structure of this protein. On the other hand, MgsA has been shown to be an improtant replication fidelity protein through its interaction with translesion synthesis byproducts. I intend to focus on characterizing the interactions by which MgsA functions.