Position title: Microbiology Doctoral Training Program
- Nancy Keller
Secondary Metabolites and the Pathogenesis of Aspergillus fumigatus
My research involves investigating the regulation, biosynthesis, and physiological effects of novel isocyanide-containing secondary metabolites found in the opportunistic human pathogen Aspergillus fumigatus. I will also study their impact on a host-pathogen interactions using the zebrafish model. Since isocyanide-containing compounds have already been shown to act as virulence factors when produced by certain microorganisms and that these compounds act as chelators of various metals, they make an attractive secondary metabolite to investigate.