Current Research

Alternative splicing creates multiple protein isoforms from one gene that can have gain- or loss-of-function compared to the best-studied protein isoform. Alternative splice variants of the transcription factor Estrogen Receptor alpha have been detected at the RNA level in breast cancer samples.  I have individually expressed these isoforms in human cell lines and am working to characterize them.  I am especially interested in how the variants’ transcription factor activity differs, both phenotypically and mechanistically