Uzziah Urquiza

Current Research

Nucleotide Salvage & its Role in Macrophage Function

In the Fan lab, we investigate how metabolic reprogramming occurs in macrophages and how this reprogramming coordinates immune cell function. My project focuses on nucleotide metabolism and the role of the salvage enzyme, HPRT, in macrophage function. During classical activation by inflammatory signals, macrophages undergo dramatic shifts in nucleotide metabolism, transitioning from de novo synthesis pathways to salvage mechanisms. This metabolic remodeling is driven primarily by nitric oxide, which simultaneously regulates multiple enzymes in nucleotide metabolism pathways. I am interested in determining the mechanisms by which HPRT-dependent purine salvage impacts critical macrophage functions including migration, phagocytosis, and cytokine production. My research also explores the significance of these metabolic shifts in host-pathogen interactions, as nucleotide metabolism may create competitive environments affecting pathogen growth within macrophages. Through this work, I aim to uncover fundamental principles of immunometabolic regulation with potential implications for inflammatory and infectious diseases.